After applying Trental, large capillaries and vessels become more durable and elastic, tissue nutrition is regulated.
Active component of the drug - pentoxifylline - dilutes the blood, changes its chemical composition for the better, slightly dilates the blood vessels.
This drug enhances the blood supply of the limbs, accelerates energy metabolism in the cerebral cortex, has a positive effect on the central nervous system.
What happens when taking the drug?
Taking Trental 100 or 400 orally, the active substance pentoxifylline is absorbed quickly and almost completely. After almost complete absorption, he is involved in the body's metabolic system.
Pentoxifylline is completely amenable to the exchange processes , more than 90% is utilized through the kidneys, with urine. However, excretion of the active substance may be delayed in patients suffering from renal dysfunction.
In patients susceptible to impaired liver function, the drug is delayed in the body for longer, since it will also take longer to digest.
Pentoxifylline is actively processed in the liver and erythrocytes. The most known cleavage products are metabolite-1 and metabolite-5, which are formed in as a result of the oxidation process. These metabolites have the same pharmacological properties as pentoxifylline.
More than 90% of the active substance is excreted with urine, and 3-4% - with calories.
The substance comes to a half-life after 1.1 hours( a dose of 100 g.).In patients with severe hepatic insufficiency, the half-life of pentoxifylline increases.
Pentoxifylline has a high rate of excretion from the body ( 4500-5100 ml per minute).
If the patient suffers from impaired renal function, the split product is excreted longer.
The drug is used with for the following diseases:
It is worth to abstain from Trental if is yours:
works The instruction for use indicates that the tablet Trenal increases the blood flow of the , due to the effect on the possibility of deformability of red blood cells. Also, it lowers the coagulability of platelets, thereby reducing superhuman blood.
The drug increases microcirculation in areas with impaired blood circulation.
Active substance - pentoxifylline, reduces the effect of phosphodiesterase and accumulates cAMP in the cells of the vascular musculature. Thus, the clearance in the vessels increases due to their relaxation.
The drug is available in different forms, respectively, and the application will be different.
Trental ampoules are administered by drip or intravenous( jet).For the infusion solution use solution Ringer , sodium chloride 0.9% or glucose 5%.Usually, prescribe 100-600 mg, 1 or 2 times a day.
In case of severe circulatory disorders, the injection may last for 24 hours( then the dose is calculated relative to the patient's weight), usually 6 mg / kg per hour.
Intravenous jet injection: not more than 100 mg and not less than 5 minutes. Assign 1-2 times a day. It must be ensured that the patient maintains a horizontal position.
If necessary, injections are combined with Trental tablets.
Dosage and time of application are appointed individually by the attending physician. Usually, prescribe 2-4 tablets, 2-3 times a day. The tablet is washed down with water without chewing.
Recommended after eating.
The total allowable dose of pentoxifylline( and injection, and tablets): not more than 1200 mg per day.
The instructions for use will be incomplete if you do not examine the dosage of Trental tablets in the in different situations:
Trental 100 and Trental 400 are characterized by the concentration of Pentoxifylline .
According to the instructions of Trental 400, is used for more aggressive treatment of in complicated cases.
However, regardless of the disease, Trental 100 is prescribed to people with unstable blood pressure , a number of heart diseases( mentioned above).
In cases of use of large doses of the drug, may occur following reactions:
Possible manifestations indicated in the item "overdose" in the form of an individual reaction of the body( not exceeding the daily norm of the drug).After the drug is withdrawn or the dosage is reduced, the symptoms should disappear.
After long-term use of the drug, is possible such reactions:
If you can not afford Trental, analogues of this drug, worthy of attention, will always be found. In order not to make a mistake and to choose a worthy replacement for an expensive drug, read our article.
Thrombosis is a very dangerous disease and a real scourge of people who have a low-activity lifestyle. Prevention of thrombosis of the veins of the lower extremities is a solvable task.
Thorough monitoring of the administration of the drug to patients with elevated blood pressure, arrhythmia, impaired renal function, liver, increased bleeding, diabetes mellitus - to select an individually acceptable daily allowance, starting at low dosages.
Otherwise, you can trigger adverse reactions.
When using Trental ampoules simultaneously with anticoagulants, it is necessary to monitor the clotting factor of the blood. For patients who have recently undergone surgery, requires careful monitoring of the level of hemoglobin and hematocrit .
For the elderly, the daily dose is reduced. Smoking negatively affects the effectiveness of treatment.
Pentoxifylline enhances the action of drugs that reduce the pressure of ( ACE, inhibitors, nitrates).
Also it can enhance the effect of the drug directed to the blood coagulation function( thrombolytics, anticoagulants), antibiotics:
The drug is contraindicated in pregnancy. Breastfeeding stops for the period of treatment.
Studying the instruction for the use of Trental, both in ampoules and tablets, it is important to note this important nuance.
About the drug Trental left a large number of reviews of doctors and patients.
Semen: "A wonderful tool. To me it or him have registered at a hearing loss( 1 stage).Not only did the hearing improve, the general condition improved. It seems that the blood supply of the whole body has increased. I will definitely drink it 2 times a year - not less than a month. "
Mik3: "All is well, it was prescribed because of the symptoms of increased blood pressure and eye pressure. The effect was, as in the instructions indicated. Negative did not notice anything. "
Olga: "I was prescribed injections, with saline solution. Immediately the pressure dropped, nausea started, but then the condition returned to normal. The second injection increased the pressure for some reason, the respiration began. Probably, the dosage is not mine. I'll consult the doctor. "
Dr. Inga: "This is perhaps one of the few drugs that has the same opinion about in patients and doctors , as its effectiveness is undeniable. However, before starting a course of treatment, it is necessary to provide the doctor with a complete medical history in order to avoid side effects.
In case of health problems, which are mentioned in the instructions( dosage and concomitant diseases), it is desirable to select an acceptable standard individually. "
In this case, the dosage is selected taking into account the individual characteristics of the organism.
After the instruction on the use of Trental is studied, we learn what the price of the drug is in Russian pharmacies.
Pentin, Pentohexal, Pentoxifylline, Pentamon, Aguparin, Arbiflex, Vasonitis.
All of these drugs contain pentoxifylline.
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